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Hamlet—son of the late king and nephew of the present king, claudius claudius—king of denmark, hamlet's uncle and brother to the former king. Abstractbackground a life-course perspective is essential in understanding the determinants of higher-level functional limitations we examine the impact of a. Hypertension, or elevated blood pressure, constitutes a major public health burden that affects more than 1 billion people worldwide and contributes to ~9 million.